Cornification defect in the golden retriever: clinical, histopathological, ultrastructural and genetic characterisation

Veterinarians have recognised a nonpruritic skin disease in the Golden retriever breed characterised by excessive scaling of large, variably pigmented flakes of skin in otherwise healthy dogs. This prospective case series describes clinical, histopathological, ultrastructural and genetic features of this cornification defect in 17 affected dogs. The condition affects young dogs of either sex and is characterised by symmetrical, predominantly ventro-lateral scaling and hyperpigmentation of the trunk. Histopathological and ultrastructural changes of the stratum corneum are suggestive of delayed degradation of corneodesmosomes. A genetic aetiology is proposed and a single-trait autosomal recessive mode of inheritance discussed.     

The cadmium status of horses from central Europe depending on breed, sex, age and living area

The Cd status of animals is best reflected by kidneys and much worse by liver and hair. Breed (heavy- and warm-blooded horses) only took an insignificant effect on the Cd content of kidneys and liver. On the average, however, warm-blooded horses stored more Cd than heavy ones. Geldings from Cd-exposed living areas accumulated insignificantly more Cd in liver, kidneys and hair than mares. The influence of age on the Cd content of kidneys and liver of Cd-exposed horses was significant. The Cd exposure of a living area was very well reflected by kidneys and liver. On the average, horses from two areas with nonferrous metal smelting stored 1000 mg Cd/kg kidney dry matter and 100 to 200 mg Cd/kg liver dry matter. The highest Cd concentration of the kidneys of horses amounted to 2.6 and 2.3 g/kg dry matter, resp.     

The supply of wild ruminants with major and trace elements. 1. The cadmium content of winter grazing and the cadmium status of red deer, fallow deer, roes and moulons

The Cd-determination of 10 different winter grazings for wild ruminants in seven different biotopes showed significant differences of the habitats resulting from the previous Cd-emission of metallurgy smelting non-ferrous metals. The winter grazing of the Tharandt Forest and the Harz mountains contained significantly more Cd than that of the Lower Flaming hills, the western Erzgebirge and the northern agrarian areas. The bark and the tips of conifer twigs, twigs of oak and mountain ash, bilberry and heather plants, i. e. perennial plants resp. parts of plants proved to be particularly rich in Cd. On an average, wild ruminants consume more Cd than domesticated ruminants, which do not consume parts of perennial plants. The rumen contents of all wild ruminants contained, with 0.20 to 0.25 mg/kg dry matter more Cd than could be expected from the content of the grazing. In the Cd-contaminated areas the amount of Cd in the rumen contents too showed the Cd-load. The kidneys, livers and the covering hair of a total of 172 head red deer, roes and mouflons reflected the Cd-load and the dependence of the Cd-level on the age. The Cd-concentration ascertained in the organs of the wild ruminants was compared with that of sheep and cattle. The, on an average, higher Cd-load of the wild ruminants was confirmed. The kidneys of wild ruminants older than five years should, as a general principle, not be eaten and neither should the livers of animals from Cd-contaminated biotopes. The limb defects of mouflons from Cd-contaminated areas are discussed in connection with Cd-induced secondary Cu-deficiency resp. Mn- and Zn-deficiency. A reference is made to further works.     

Management of concurrent patellar luxation and cranial cruciate ligament rupture using modified tibial plateau levelling

Objectives : To evaluate a novel surgery aimed at managing concurrent medial patellar luxation (MPL) and cranial cruciate ligament (CCL) ruptures in dogs weighing more than 30 kg. Methods : Tibial plateau levelling osteotomy (TPLO) and femoral trochleopasty were performed. The principal tibial fragment was laterally translated by 3 to 6 mm and was externally and abaxially rotated to create a wedge measuring 1·5 to 2·5 mm at the medial and cranial aspect and 1 to 3 mm at the medial and distal aspect of the tibial plateau fragment. The fragments were stabilised with a narrow TPLO plate. Results : Thirteen surgeries were performed in 12 dogs with a mean weight of 39·8 kg. The mean postoperative tibial plateau slope was 8·1°. Additional surgery was required in two cases, one due to failure of fixation and another due to screw breakage. The mean lameness score was 3·5 (out of 5) before surgery, 0·7 after 8 to 12 weeks, and 0·3 at final follow-up. Median follow-up was 1115 days (range, 270 to 2040 days). No patella luxated after surgery. Clinical Significance : MPL and CCL ruptures may be successfully managed by performing a TPLO and simultaneously altering the relationship of the principal and tibial plateau fragments during surgery.     

Charging effects on bonding and catalyzed oxidation of CO on Au8 clusters on MgO

Gold octamers (Au8) bound to oxygen-vacancy F-center defects on Mg(001) are the smallest clusters to catalyze the low-temperature oxidation of CO to CO2, whereas clusters deposited on close-to-perfect magnesia surfaces remain chemically inert. Charging of the supported clusters plays a key role in promoting their chemical activity. Infrared measurements of the stretch vibration of CO adsorbed on mass-selected gold octamers soft-landed on MgO(001) with coadsorbed O2 show a red shift on an F-center-rich surface with respect to the perfect surface. The experiments agree with quantum ab initio calculations that predict that a red shift of the C-O vibration should arise via electron back-donation to the CO antibonding orbital.     

A Module to Calculate Primary Particulate Matter Emissions and Abatement Measures in Europe

Primary particulate matter is emitted directly into the atmosphere from various anthropogenic and natural sources such as power plants (combustion of fossil fuels) or forest fires. Secondary particles are formed by transformation of SO₂, NO_x, NH₃, and VOC in the atmosphere. They both contribute to ambient particulate matter concentrations, which may have adverse effects on human health. Health hazards are caused by small particulate size, high number of especially fine (< 2.5 µm) and ultra-fine (< 0.1 µm) particles and/or their chemical composition. As part of an integrated assessment model developed at IIASA, a module on primary particulate matter (PM) emissions has been added to the existing SO₂, NO_x, NH₃ and VOC sections. The module considers so far primary emissions of total suspended particles (TSP), PM₁₀ and PM_2.5 from aggregated stationary and mobile sources. A primary PM emission database has been established. Country specific emission factors for stationary sources have been calculated within the module using the ash content of solid fuels.     

Invasive plant suppresses charismatic seabird - the construction of attitudes towards biodiversity management options

Public attitudes towards biodiversity issues and the value judgments underlying biodiversity management and conservation are still poorly understood. This has raised serious concerns regarding the effective use of public participation in biodiversity policy making. We conducted quantitative face-to-face interviews with members of the general public in southeast Scotland to assess attitudes towards biodiversity management and examine attitude formation. For this, we applied social psychological attitude-behaviour theories to a case study investigating biodiversity management options for an island ecosystem in which the abundance of a charismatic seabird, the Atlantic puffin (Fratercula arctica) is compromised by the expansion of a tall invasive plant, tree mallow (Lavatera arborea). We found that attitudes as expressed by members of the public are informed by both value- and knowledge-based elements. Our research provides clear support for the notion that, in a conservation context, value-based principles matter to the public. Out of a set of seven conservation-related values, ‘balance’ and ‘naturalness’ were important factors that related strongly to the respondents’ attitudes. These relationships were even stronger for individuals emotionally involved with the topic. Other value-based principles such as uniqueness, autochthony and endangeredness of the species involved appeared to be of lesser relevance. The findings provide evidence that attitudes can be considered as distinct constructs that offer valuable and meaningful information to biodiversity policymakers and managers, and allow empirical insights into the way value judgments influence biodiversity management and conservation.